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Semiquantitative mIBG (Curie) Score

COG modified Curie scoring (Ady 1995; Yanik et al. 2018)

Sums MIBG-avid disease burden across nine skeletal zones plus a soft-tissue zone, each graded 0-3, to yield the Curie score (0-30) used for neuroblastoma staging, response assessment, and prognosis.

Also searched as: neuroblastoma · Curie score · scintigraphy · pediatric oncology

Interactive diagramClick a skeletal zone to cycle its score from 0 to 3
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03 — click a zone to cycle its score; zone 10 (soft tissue) stays a field below
Zone 1: Head / skull
Zone 2: Cervical and thoracic spine
Zone 3: Ribs, sternum, clavicles (chest)
Zone 4: Lumbar and sacral spine
Zone 5: Pelvis
Zone 6: Proximal upper extremities (humeri)
Zone 7: Distal upper extremities
Zone 8: Proximal lower extremities (femurs)
Zone 9: Distal lower extremities
Zone 10: Soft tissue
Information
Incomplete input
  • Please provide: zone scores for Zone 1, Zone 2, Zone 3, Zone 4, Zone 5, Zone 6, Zone 7, Zone 8, Zone 9, Zone 10.

How this tool works

The Children's Oncology Group modified Curie method grades each of ten anatomic regions on planar I-123 or I-131 MIBG scans: 0 for no abnormal uptake, 1 for a single avid focus, 2 for multiple foci, and 3 for avidity involving more than half of the region (for soft tissue, more than half of the chest or abdomen). The zone scores add to a maximum of 30. Scores above 2, particularly at the end of induction chemotherapy, identify patients with markedly inferior event-free and overall survival.

References

Implemented from the cited published sources. Educational use only; confirm against current guidelines before clinical use.

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