Mayo Clinic Solitary Pulmonary Nodule Model
Swensen 1997 (Mayo Clinic)Estimates the pre-test probability that a radiologically indeterminate solitary pulmonary nodule is malignant from age, smoking, remote cancer history, nodule diameter, spiculation and upper-lobe location (Swensen 1997).
Also searched as: malignancy risk · SPN · logistic model · lung cancer
Information
Incomplete input
- Please provide: patient age (years), current or former smoking (yes/no), extrathoracic cancer >5 years ago (yes/no), nodule diameter (mm), spiculation (yes/no), upper-lobe location (yes/no).
How this tool works
The Mayo Clinic model was derived from 629 patients with newly detected nodules 4–30 mm and validated externally with an AUC around 0.80. It combines three patient factors (age, ever-smoking, extrathoracic cancer more than 5 years earlier) with three imaging factors (largest diameter, spiculated margin, upper-lobe location) in a single logistic equation. Because it was derived in a referral population with a 23% malignancy prevalence, it is best applied to incidental clinical nodules rather than screening LDCT cohorts, where the Brock model is preferred. The equation reproduced here is verified verbatim against the published Schultz 2008 validation, whose two worked examples this implementation reproduces exactly.
References
- Schultz EM et al. Thorax 2008;63:335-41 (validation; equation verified here)
- Swensen SJ et al. Arch Intern Med 1997;157:849-55 (PubMed)
- Radiopaedia: solitary pulmonary nodule
Implemented from the cited published sources. Educational use only; confirm against current guidelines before clinical use.
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