Choi Criteria for GIST Response
Choi criteria (Choi et al., 2007)Evaluates gastrointestinal stromal tumor response to tyrosine-kinase inhibitors using both tumor size and CT attenuation, classifying the examination as CR, PR, SD or PD by the Choi criteria.
Also searched as: gastrointestinal stromal tumor · imatinib · Hounsfield · tumor density · tumor response
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Incomplete input
- Please provide: baseline sum of longest diameters, current sum of longest diameters.
How this tool works
GISTs responding to imatinib often become hypodense and homogeneous long before they shrink, so the Choi criteria combine size with tumor density measured in Hounsfield units on contrast CT. Partial response is a fall of at least 10% in the sum of the longest diameters of target lesions OR a fall of at least 15% in mean tumor attenuation, with no new lesions and no obvious progression of non-measurable disease. Progressive disease is a size increase of at least 10% that is not rescued by a 15% density drop, the appearance of new lesions, or new or enlarging intratumoral nodules. Complete response requires disappearance of all lesions without new lesions. Density is measured in a representative region of each target lesion on a consistent contrast phase.
References
- Choi H et al. Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria. J Clin Oncol 2007;25:1753-1759.
- NCCN Task Force Report: Update on the Management of Patients with Gastrointestinal Stromal Tumors, Table 5 (Choi criteria reproduction)
Implemented from the cited published sources. Educational use only; confirm against current guidelines before clinical use.
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